Microarray cDNA Dataset Analysis Reveals Potential Genes Associated with Type 2 Diabetes Mellitus for Further Treatment Exploration

Type 2 diabetes mellitus (T2DM) is an intricate and inadequately treatable metabolic disorder that requires modified treatment by identifying genetic variants as potential drug targets. In this study, we performed the system-level analysis of T2DM-related cDNA dataset revealed 5 significant differentials expressed genes (DEGs) including ABRA, CYR61, NR4A1, KY, TMEM131 source genes. Among, these genes, 3 were down-regulated up-regulated. The biological function gene ontology showed association with cell apoptosis, communication, signal transduction, insulin resistance. These are majorly in multiple tissues specifically brain, lungs, pancreas, immune cells. protein-protein network interaction important signature proteins FOS, IGFN1, UBC, CTNB1, ITB5, JUN, HIF1A, p53, other This study would be helpful to understand etiology T2DM also improve development new treatments identification associated T2DM.